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Nothing can be done to remedy a tire which has been flat-spotted due to locking up the wheels ... but couldn't imagine how you could lock the brakes for that long to achieve this. We're not talking hyper-sensitive F1 cars, after all.
I'd have the wheels and tyres rebalanced, you might find that some weights have fallen off. Vibrational 'harmonics' come and go at certain speeds and certain rev ranges. You could drive it at 75mph and perhaps find that the sound diminishes - but that doesn't mean you should simply drive it that fast all day long *lol*. This noise could be anything, tbh ... any one of the major drivetrain bearings etc. Does the noise/vibration increase if you're really going hard into a corner, for example?
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